Physiological role and diagnostic value of anti-Mullerian hormone in pediatrics
نویسندگان
چکیده
Background. Anti-Mullerian hormone (AMH) has now gained popularity as a marker of ovarian reserve. It is important to determine the place and role AMH in children. The purpose this work was analyze data scientific literature on pediatric practice. Materials methods. A review PubMed conducted, limiting itself articles English updating search February 2022. term “anti-Mullerian hormone”. total 437 manuscripts were found, including 37 articles. gradually narrowed with filters clinical trials systematic reviews 75 references original then checked ensure complete review. responsible for differentiation gonads, provokes regression Mullerian ducts male fetus, correlates karyotype, sexual development, levels luteinizing hormone, follicle-stimulating its serum reflect reserve women, even childhood. Serum high from prenatal life puberty. In postnatal period, secretion by testes stimulated strongly inhibited androgens. value testicular tissue men differences development cryptorchidism, well assessment persistent duct syndrome. Determination useful assessing function gonads without need stimulation tests guides etiological diagnosis childhood hypogonadism. used prognostic fertility. use criteria developed adult women problematic adolescent girls, signs associated polycystic ovary syndrome are normal phenomena can be an additional criterion adolescents. However, lack international standard limits comparisons between analyzes. Conclusions. broad diagnostic utility pediatrics, but interpretation often complex should made context not only age sex, also stage puberty child. Recognition beyond maturation may lead new therapeutic applications that will further expand
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ii To my family and friends who supported me throughout this journey iii ACKNOWLEDGMENTS This project would not have been possible without Drs. Donna and Mark Santillan. I would like to thank them both for their endless support and advice in the development of this program. Thanks to Dr. Kristi Borowski for allowing us access to her serum tissue bank and birth certificate data, and to Dr. Ben L...
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ژورنال
عنوان ژورنال: CHILD`S HEALTH
سال: 2022
ISSN: ['2307-1168', '2224-0551']
DOI: https://doi.org/10.22141/2224-0551.17.6.2022.1532